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stat5 gene  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology stat5 gene
    Stat5 Gene, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat5 gene/product/Santa Cruz Biotechnology
    Average 93 stars, based on 29 article reviews
    stat5 gene - by Bioz Stars, 2026-02
    93/100 stars

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    The mechanism of miR-30b targeted CBX3 in activating <t>JAK2/STAT3</t> pathway, thus regulating ESCC cell proliferation, apoptosis, and migration. A. The Western blot showing the protein expression of p-JAK2/JAK2, p-STAT3/JAK3, and p-STAT5/STAT5 in TE-1 cells transfected with miR-30b mimic, mimic control, miR-30b mimic plus blank control, and miR-30b mimic plus pc-CBX3. B. The regulatory mechanism. Red nodes indicate upregulation while blue nodes indicate downregulation. **P<0.01 and ***P<0.001 compared with corresponding control.
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    The mechanism of miR-30b targeted CBX3 in activating JAK2/STAT3 pathway, thus regulating ESCC cell proliferation, apoptosis, and migration. A. The Western blot showing the protein expression of p-JAK2/JAK2, p-STAT3/JAK3, and p-STAT5/STAT5 in TE-1 cells transfected with miR-30b mimic, mimic control, miR-30b mimic plus blank control, and miR-30b mimic plus pc-CBX3. B. The regulatory mechanism. Red nodes indicate upregulation while blue nodes indicate downregulation. **P<0.01 and ***P<0.001 compared with corresponding control.

    Journal: International Journal of Clinical and Experimental Pathology

    Article Title: MicroRNA-30b targets CBX3 and regulates cell proliferation, apoptosis, and migration in esophageal squamous cell carcinoma via the JAK2/STAT3 signaling pathway

    doi:

    Figure Lengend Snippet: The mechanism of miR-30b targeted CBX3 in activating JAK2/STAT3 pathway, thus regulating ESCC cell proliferation, apoptosis, and migration. A. The Western blot showing the protein expression of p-JAK2/JAK2, p-STAT3/JAK3, and p-STAT5/STAT5 in TE-1 cells transfected with miR-30b mimic, mimic control, miR-30b mimic plus blank control, and miR-30b mimic plus pc-CBX3. B. The regulatory mechanism. Red nodes indicate upregulation while blue nodes indicate downregulation. **P<0.01 and ***P<0.001 compared with corresponding control.

    Article Snippet: The primary antibodies to the CBX3, BAX, BCL2, JAK2, p-JAK2, STAT3, p-STAT3, p-STAT5, and GAPDH (1:1000) genes were purchased from Cell Signaling Technology (Beverly, MA, USA) and were used for incubating the membranes overnight at 4°C, followed by incubation with a horseradish peroxidase (HRP)-labeled secondary antibody (1:1000 dilution) at 37°C for 1 h. Subsequently, the protein bands were detected by an enhanced chemiluminescence (ECL) detection system (GE Healthcare, Piscataway, NJ, USA).

    Techniques: Migration, Western Blot, Expressing, Transfection, Control